D-xylose absorption in non-chronic diarrhea AIDS patients with the wasting syndrome
Luangjaru, S.; Ruxrungtham, K.; Wisedopas, N.; Mahachai, V.
Journal of the Medical Association of Thailand 86(Suppl): S477-S483
2003
ISSN/ISBN: 0125-2208 PMID: 12930028 Document Number: 2214
Objective: To compare the intestinal absorptive capacity, permeability function and duodenal histopathology in human immunodeficiency virus (HIV) patients with or without wasting syndrome who had not suffered from chronic diarrhea. Method: Adult HIV patients who attended Chulalongkorn Hospital were included. The subjects were classified into wasting and non-wasting groups (group I and group II). 25 g oral D-xylose test, oral phenolsulfonephthalein test and duodenal histopathology were performed. Results: Of thirty-two HIV patients, aged between 25-50 years enrolled, there were 18 and 14 patients in group I and group II, respectively. In both groups, the baseline data, permeability function and histopathology were similar. Intestinal absorptive capacity was statistically different, i.e. 5-hour urine D-xylose was 3.96+-2.81 g and 5.95+-2.47 g in group I and group II respectively (p< 0.05). Conclusion: This study demonstrated that D-xylose absorption was decreased in non-diarrheal, wasting HIV infected patients. Abnormal absorptive capacity is a common phenomenon found in HIV patients with wasting syndrome as determined by standard 25 g oral D-xylose test.