Interaction of pipolfen and suprastin with human serum albumin depending on the pH of the medium and its calcium ion content
Bender, K.I.; Lutsevich, A.N.
Farmakologiia i Toksikologiia 46(6): 59-63
1983
ISSN/ISBN: 0014-8318 PMID: 6653761 Document Number: 220664
Experiments made with the use of equilibrium dialysis and differential spectrophotometry have shown that pipolfen and difenhydramine interact actively with human serum albumin at pH 6.8-7.4. Calcium ions have been demonstrated to activate the interaction of pipolphen and diphenhydramine with albumin.