A demonstration of neutrophil accumulation in the pulmonary vasculature during haemodialysis
Dodd, N.J.; Gordge, M.P.; Tarrant, J.; Parsons, V.; Weston, M.J.
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association 20: 186-189
1983
ISSN/ISBN: 0071-2736 PMID: 6657655 Document Number: 219602
111Indium oxine labelled autologous neutrophils were used to investigate neutropenia occurring during haemodialysis. Continuous surface counts demonstrated accumulation of labelled neutrophils in the lung, reaching a peak at 15 minutes after commencing dialysis, coincident with a fall in arterial blood and dialyser radioactivity, and a fall in arterial blood neutrophil count. Lung radioactivity returned to baseline after one hour implying reflux of labelled neutrophils into the circulation, whilst dialyser activity rose progressively and remained high even after washback of blood from the dialyser reflecting accumulation of neutrophils on the membrane.