A case of pulmonary infiltrates associated with a neutrophil-specific antibody transfusion reactions
Kan, K.; Tase, C.; Ohto, H.; Isosu, T.; Niitsu, K.
Masui. Japanese Journal of Anesthesiology 44(1): 92-95
1995
ISSN/ISBN: 0021-4892 PMID: 7699831 Document Number: 441678
A normovolemic pulmonary edema associated with blood transfusion developed in a 38-year-old woman during gynecological operation. Bilateral pulmonary infiltrates and profound leucopenia (700 cntdot mu-l-1) were observed. An antibody reactive with the recipient's neutrophils was found in a donor and an antibody reacting with the lymphocytes of the recipient was identified in another donor. Both donors were multiparous women. Respiratory failure was improved with mechanical ventilation but chest X-ray showed pulmonary infiltrates for the next 3 days. The white blood cell count rose to 2900 cntdot mu-l-1 in the next day, and it took 2 weeks to be normalized. Transient pulmonary infiltrates can be caused by antileukocyte antibodies passively transfused by multiparous donors.