Vaginal delivery and low immunity are strongly associated with high-grade cervical intraepithelial neoplasia in a high-risk population
Russo, E.; Kupek, E.; Zanine, R.M.
Journal of Lower Genital Tract Disease 15(3): 195-199
2011
ISSN/ISBN: 1526-0976 PMID: 21436727 DOI: 10.1097/lgt.0b013e31820918eaDocument Number: 219410
To test the association between high-grade cervical intraepithelial neoplasia (CIN), including CIN 2 and CIN 3, and the main risk factors established in the literature, such as age, early onset of sexual activity, use of hormonal contraception, smoking, sexually transmitted diseases, immunosuppression, the number of deliveries, and abortions. A cross-sectional study using medical records of 531 women examined for a period of 2 years in a referral center in southern Brazil. Multivariate logistic regression analysis confirmed the following risk factors for high-grade CIN: smoking (odds ratio [OR] = 1.92, with 95% confidence interval [CI] = 1.13-3.27), immunosuppression (OR = 3.45, 95% CI = 1.61-7.43), abortion (OR = 2.15, 95% CI = 1.07-4.35) and 2 or more abdominal deliveries (OR = 3.46, 95% CI = 1.90-6.27). Cervical cancer screening should give special attention to the women with the above profile of risk factors by shortening the time interval between the screens.