Hematopoiesis on cellulose ester membranes (CEM) . V. Enrichment of CEM by demineralized mouse bone matrix powder
Knospe, W.H.; Husseini, S.G.; Adler, S.S.; Reddi, A.H.
Experimental Hematology 11(10): 1021-1026
1983
ISSN/ISBN: 0301-472X PMID: 6662213 Document Number: 218892
Mouse bone matrix powder was implanted subcutaneously or put into folded tubular cellulose ester membranes (CEM) and implanted i.p. Calcification and new bone formation did not develop. Sinusoidal vascularization of the matrix developed by 3 to 4 wk. Stromal cells such as fat cells and fibroblasts were present by 4 wk. Hematopoiesis was absent except for rare foci of granulopoiesis on some of the CEM at 6 wk. Rat bone matrix implanted subcutaneously into mice and mouse bone matrix implanted subcutaneously into rats failed to induce new bone formation or hematopoiesis.