Influence of mast cells on thyroid function
Bianco, A.C.; Nunes, M.T.; Douglas, C.R.
Endocrinologia Experimentalis 17(2): 99-106
1983
ISSN/ISBN: 0013-7200 PMID: 6411454 Document Number: 217646
The role of mast cells on thyroid gland function was studied with respect to 2 sites of thyroid control: the thyroid gland and the hypothalamus-pituitary sytem. The treatment with disodium cromoglycate (mast cells stabilizer) partially blocked the TSH actions on thyroid gland, thus evidencing the thyroidal mast cells as an intermediary factor of TSH actions on thyroid gland. Both T4 (mast cells disrupter polymer) was administered, concomitantly with increased 1 and 24 h radioiodine uptake. T/S ratio, 131Pb I and TSH serum concentration. The alterations were not observed in the rats pre-treated with disodium cromoglycate and administered with BW 48-80. BW 48-80 promoted an elevation of TSH serum concentration in T4-primed thyroidectomized rats. This phenomenon was completely prevented by the pretreatment with cromoglycate which confirmed the active participation of mast cells on TRH and/or TSH secretion.