In vivo effects of cefoperazone in local infection
Kumano, K.; Nishida, N.; Hayashi, T.; Kasuga, C.; Watanabe, Y.; Yasuda, T.; Saikawa, I.
Japanese Journal of Antibiotics 36(12): 3450-3455
1983
ISSN/ISBN: 0368-2781 PMID: 6325755 Document Number: 217642
The in vivo antibacterial activity and the penetration into inflammatory tissues of cefoperazone (CPZ) were compared with those of cefotiam (CTM) in local infection systems using mouse subcutaneous abscess and rat granuloma pouch. The serum levels of CPZ in subcutaneous abscess in mice caused by Staphylococcus aureus F-230 (penicillinase producing strain) were lower than that of CTM, but there was no significance between the therapeutic effects of both drugs. The same results were obtained using Staphylococcus aureus F-196 (penicillinase non-producing strain). When infected with Enterobacter cloacae H-27 (cephalosporinase producing strain) in rat granuloma pouch, the exudate levels of CTM were lower than those of CPZ. Judging from these results, it was suggested that CPZ was a useful antibiotic for the treatment of bacterial-inflammatory tissues.