Genetics of dystrophic epicardial mineralization in DBA/2 mice
Brownstein, D.G.
Laboratory Animal Science 33(3): 247-248
1983
ISSN/ISBN: 0023-6764 PMID: 6308343 Document Number: 217441
The genetics of the condition was studied, using 6- to 8-wk-old hybrids and recombinant inbred mice derived from DBA/2J (high prevalence) and C57B1/6J (low prevalence) mice. DBA/2J mice of both sexes were uniformly affected. No cases were seen among 32 F1 mice and 82 F2 mice. Six of 31 backcross progeny obtained from F1 females backcrossed to DBA/2J males were affected, as were 2 of 25 recombinant inbred strains. The results suggest that dystrophic epicardial mineralization is determined by 3 or 4 unlinked autosomal recessive alleles.