Bone structure, composition, and mineralization
Boskey, A.L.; Posner, A.S.
Orthopedic Clinics of North America 15(4): 597-612
1984
ISSN/ISBN: 0030-5898 PMID: 6387574 Document Number: 225003
Bone structure and function are dependent on complex interactions between cells, matrix, cell-derived factors, and systemic factors. The deposition of mineral in bone, which enables the skeleton to function properly, is described as a four-step process of matrix modification, crystal nucleation, crystal growth, and remodeling. Insight into the function of bone components in the mineralization process is provided by in vitro studies and analysis of abnormal calcifications.