HLA antigens in renal cell carcinoma
Kantor, A.F.; McLaughlin, J.K.; Blattner, W.A.; Bach, F.H.; Blot, W.J.; Schuman, L.M.; Fraumeni, J.F.
Cancer Research 43(5): 2330-2333
1983
ISSN/ISBN: 0008-5472 PMID: 6831458 Document Number: 217319
HLA antigen type was studied in 35 renal cell carcinoma patients who had bilateral disease, an early age of onset (less than age 45), or a family history of kidney cancer. Increased frequencies of the single-locus antigens HLA-DR8 (relative risk, 3.3) and HLA-Bw44 (relative risk, 2.1) and a deficit of HLA-DR1 (relative risk, 0.4) were found. Although based on small numbers, the relative excess was highest among persons phenotypically HLA-Bw44DR8. A higher frequency of the three-locus phenotype HLA-A3B7DR2 was also noted. The unusual HLA patterns were most pronounced among patients of German or Scandinavian origin, population groups reported to have an elevated risk of renal cancer.