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Minute chromosomes in a case of chronic Ph1-positive myeloid leukemia

Suciu, S.; Neamtu, S.; Petrov, L.; Marinca, E.; Giurgiuman, M.

Folia Haematologica 110(6): 942-947

1983

ISSN/ISBN: 0323-4347
PMID: 6200408
Document Number: 217149
Minute chromosomes (mins) were found in all bone marrow cells in a 62-year-old woman with Ph1 positive chronic myeloid leukemia. The cells had a range of 39 to 50 chromosomes with a mode of 46. The examined metaphases had a variety of numerical and structural chromosome abnormalities, as well as 2 to 6 minute chromosomes. Our case supports the assumption that there may be a correlation between the presence of mins in leukemias and the resistance of the cells to chemotherapy or the rapid progression of the disease.

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