Polyadenylated RNA and poly-A segments in the splenic cells of mice with virus-induced Rauscher leukemia
Smirnova, I.A.; Nakonechnyĭ, N.V.
Voprosy Meditsinskoi Khimii 29(6): 63-69
1983
ISSN/ISBN: 0042-8809 PMID: 6199896 Document Number: 217086
In spleen cells of mice with Rauscher++ leukosis polyadenilation of RNA was impaired: an increase in content of Gya poly(A)+ RNA and a change in the composition of poly-A-segments were observed. In DNA of leukemic and normal cells dA-fragments were found content of which was increased in leukemic cells as compared with normal ones. Leukemic transformation appears to be accompanied by appearance of the additional poly-A-fragments in the cells.