Inhibition by tuftsin of Rauscher virus leukemia development in mice

Knyszynski, A.; Gottlieb, P.; Fridkin, M.

Journal of the National Cancer Institute 71(1): 87-90

1983


ISSN/ISBN: 0027-8874
PMID: 6575215
Document Number: 210067
The antitumor effect of tuftsin, the natural phagocytosis-stimulating peptide, on leukemia induced by Rauscher murine leukemia virus (R-MuLV) was studied in vivo in SWR inbred mice. Tuftsin was found capable of significantly increasing the survival of R-MuLV-infected mice. The peptide, when injected both ip and iv into mice, exerted its activity in a dose- and time-dependent manner. Optimal antitumor activity was achieved upon administration of 25 micrograms tuftsin 4 days before R-MuLV inoculation.

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