Circadian changes in the elimination of misonidazole in mouse
Labat, C.; Malmary, M.F.; Casanovas, A.M.; Patau, J.P.; Oustrin, J.
Research Communications in Chemical Pathology and Pharmacology 42(2): 331-334
1983
ISSN/ISBN: 0034-5164 PMID: 6658193 Document Number: 216862
Intraperitoneal doses of Misonidazole were administered at 15.00 hours and 03.00 hours to Balb c/cenlco mice standardized in controlled environmental cages for 3 weeks before the experiment. Non linear pharmacokinetic and temporal variations in the apparent half life were obtained at higher doses.
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