Mechanism of natural penicillin resistance in the causative agent of tularemia
Pavlovich, N.V.; Shimaniuk, N.I.; Mishan'kin, B.N.
Antibiotiki 28(7): 517-521
1983
ISSN/ISBN: 0003-5637 PMID: 6605111 Document Number: 216525
Beta-Lactamase and penicillinacylase were detected in the tularemia causative agent. These enzymes participated in the mechanism of natural resistance of the microorganisms to penicillins. It was shown that the growth temperature had a significant effect on the beta-lactamase activity. The penicillin resistance marker was not eliminated with the use of acridine orange, ethidium bromide or sodium dodecylsulfate.
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