The effects of a load of phenĭlalanine on glucose metabolism
Piccardo, M.G.; Rosa, M.; Russo, L.
Bollettino della Societa Italiana di Biologia Sperimentale 59(2): 167-170
1983
ISSN/ISBN: 0037-8771 PMID: 6860489 Document Number: 216392
The clinical and experimental hyperphenylalaninemic conditions seem associated with disorders of carbohydrates metabolism. Examples are the increased liver glucose turnover and the glycogen depletion under Phenylalanine load and the hyperexcretion of glucose in the urine of PKU children. We studied the effects of an acute load of Phenylalanine on Glucose-3-H3 kinetics and plasma glucose levels in adult male Wistar rats. The effects of the load were very slow and after 40 minutes we observed an increase in the rate of plasma glucose production (Ra), that in normal animals in an almost exclusive liver function. As result of this glucose production there was a modest increase in plasma glucose levels.