Power-law approximation and similarity properties of metabolic regulatory characteristics
Kholodenko, B.N.
Biofizika 28(4): 674-681
1983
ISSN/ISBN: 0006-3029 PMID: 6615906 Document Number: 214812
A simple procedure is given to estimate the parameters and error of power--law approximation of rate laws for a wide class of irreversible enzyme reactions. Conditions are formulated assuring the validity of the following similarity law of regulatory characteristics: in homological metabolic chains of different individuals steady--state flux dependences on key compound concentration can be made identical by means of scale transformation, with coefficients determined by individual parameters.