Inhibition of DNA-dependent RNA polymerase from Escherichia coli by pyran copolymer
O'Connor, D.L.; Kumar, S.A.
Biochemistry International 6(4): 489-496
1983
ISSN/ISBN: 0158-5231 PMID: 6385976 Document Number: 214713
Pyran copolymer, a potent inhibitor of DNA-dependent RNA polymerase from Escherichia coli, prevented polyribonucleotide synthesis by blocking both the initiation and elongation steps. The inhibition was noncompetitive with respect to template and nucleotide triphosphate substrates. Template binding and the stability of the nascent RNA chain were not affected by the inhibitor.
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