Impaired nerve-muscle interaction by percutaneous terphenyl exposure
Verkkala, E.; Savolainen, H.
Research Communications in Chemical Pathology and Pharmacology 41(1): 161-164
1983
ISSN/ISBN: 0034-5164 PMID: 6312516 Document Number: 214494
Rat tail muscle responses decreased in amplitude and showed polyphasia in intermittent (3 h daily for 4-8 wk) percutaneous exposure to a commercial terphenyl mixture. The gross conduction times did not change excluding demyelination as a mechanism. The exposure technique allowed an exact estimation of the absorbed dose (0.23 .+-. 0.05 g/12 cm2 skin in 3 h). This could be altered by changing the skin contact time. The described technique may be used also in the detection of local toxicity of other lipid-soluble compounds.