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A marker of human foetal endoderm defined by a monoclonal antibody involves Type 1 blood group chains

Gooi, H.C.; Williams, L.K.; Uemura, K.; Hounsell, E.F.; McIlhinney, R.A.; Feizi, T.

Molecular Immunology 20(6): 607-613

1983

ISSN/ISBN: 0161-5890
PMID: 6192330
Document Number: 212914
A marker of human embryonic endoderm and embryonal carcinoma cells recognized by a hybridoma antibody FC 10.2 is shown to involve type-1 blood group chains with the sequence Ga1.beta.1 .fwdarw. 3GlcNAc.beta.1 .fwdarw. 3Gal.beta.1 .fwdarw. 4Glc. This conclusion was reached from antigenic analysis of meconium, ovarian cyst glycoproteins, oligosaccharides and glycolipids having type-1 or type-2 blood group chains. From knowledge of saccharide sequences and blood group-related antigens in gastrointestinal tissues of man, it is deduced that the disappearance of FC 10.2 antigen from the normal, differentiated cells of the adult may results from masking by additional glycosylations or other substitutions.

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