Effects of extracorporeal blood irradiation on the lymphocyte population in chronic lymphadenosis
Heilmann, E.; Koch, K.
Folia Haematologica 110(5): 656-664
1983
ISSN/ISBN: 0323-4347 PMID: 6198249 Document Number: 212893
The surface markers of lymphocytes were detected in 18 patients with chronic lymphatic leukemia (CLL), with 9 of them being treated by means of extracorporeal blood irradiation (ECIB) and 9 of them being without any treatment. We found that B-lymphocytes were eliminated by ECIB to a higher degree than it can be recognized by the decrease of lymphocytes. As to their percentage B-cells with ME-receptors or EAC-receptors respectively were partially diminished to a higher degree than the total population of B-cells. Moreover, the pathological Ig-type could be shown to be affected predominantly. The changes of marker profiles and absolute values achieved by ECIB revealed an approach of values in treated patients to those of untreated patients. The investigations make it clear that the determination of lymphocyte subpopulation can be used not only for diagnosis and differential diagnosis of lymphatic system diseases, also for evaluating therapy effects.