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Topographic distribution of arsenous anhydride in pregnant mice using macroscopic autoradiography

Brunet, C.; Luyckx, M.; Cazin, M.

Toxicological European Research. Recherche Europeenne en Toxicologie 5(2): 55-61

1983

ISSN/ISBN: 0249-6402
PMID: 6612724
Document Number: 211749
Radioactive arsenic trioxide is given to pregnant mice in order to complete a recent pharmacokinetics study in the same species and to investigate an eventual transplacental passage, whole body autoradiographic study is performed in the mouse after a single administration of that compound considering its fast elimination process. Both in mice and foetus a fixation has particularly kept our attention: the radioactivity is well fixed in the bone marrow and it might be related to some malformations which occur in the newborns.

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