Influence of the pressing force on the physical features of sulfathiazole tablets and the dissolution rate of the active ingredient
Miseta, M.; Kedvessy, G.; Selmeczi, B.
Die Pharmazie 38(5): 326-327
1983
ISSN/ISBN: 0031-7144 PMID: 6611630 Document Number: 211597
When the pressing force increased in the examined system, so did the mechanical firmness of the tablets. A logarithmic connection exists between the pressing force and the compression strength and between the pressing force and the porosity, while the connection between the pressing force and the abrasion loss was a connection of power-function. The changing of the pressing force don't alter significantly the disintegration time of the tablets and the dissolution rate of the drug. However there is a considerable difference between the dissolution rate of the sulfathiazolee-powder and that of the tablets. The binders used in the pressing process were surface-active, therefore they accelerated the dissolution by moistening the surface of the sulfathiazol crystals.