Immunotherapy of a murine B cell tumor with antibodies and F(ab&apos;)2 fragments against idiotypic determinants of its cell surface IgM

Perek, Y.; Hurwitz, E.; Burowski, D.; Haimovich, J.; Perek, Y; Hurwitz, E; Burowski, D; Haimovich, J

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Immunotherapy of a murine B cell tumor with antibodies and F (ab') 2 fragments against idiotypic determinants of its cell surface IgM

Perek, Y.; Hurwitz, E.; Burowski, D.; Haimovich, J.

Journal of Immunology 131(3): 1600-1603

1983

ISSN/ISBN: 0022-1767

PMID: 6604103

Document Number: 211518

Anti-idiotype antibodies against the IgM of the 38C-13 murine B lymphocyte cell line and F(ab')2 fragments derived from them were checked for their therapeutic effect against the killing of mice by 38C-13 cells. Both intact molecules and the F(ab')2 fragments were effective in delaying or preventing the killing of mice by 38C-13 tumors when used in large amounts and by the appropriate routes.