Recovery of acetylsalicylic acid and indalpine (LM 5008) after buccal partitioning
Blackett, A.; Brion, N.; Turner, P.
International Journal of Clinical Pharmacology Research 3(1): 5-7
1983
ISSN/ISBN: 0251-1649 PMID: 6679508 Document Number: 210063
The recoveries were compared of acetylsalicylic acid (ASA) and indalpine (1) after buccal absorption in three trained human volunteers. Recovery of the poorly lipid soluble ASA was less than 1% at pH 5 or 8, while that of the lipid soluble I was 19% and 13% at pH 5 and 8 respectively. This difference in recovery may represent a difference in their storage within the buccal mucosa dependent on their different lipid solubilities.