Cellular kinetics in nonbullous ichthyosiforme erythroderma
Heenen, M.; Galand, P.
Annales de Dermatologie et de Venereologie 110(12): 987-991
1983
ISSN/ISBN: 0151-9638 PMID: 6666942 Document Number: 210049
An in vitro double labeling technique with 3H-Tdr has been used to study the cell renewal in three cases of lamellar ichthyosis. Each case was characterized by a rapid rate of cell proliferation as it occurs in psoriasis. But, in contrast to psoriasis, lamellar ichthyosis has no increased proportion of germinative cells and exhibits prominent granular layer. Horny layer at light microscopy is mainly orthokeratotic. This indicates that increased mitotic activity alone cannot account for the typical acanthosis of psoriasis.