Effect of a specific alloantiserum against T-suppressor cells on the resistance of mice to tuberculosis
Apt, A.S.; Abramova, Z.P.; Moroz, A.M.; Nikonenko, B.V.; Averbakh, M.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 95(5): 78-81
1983
ISSN/ISBN: 0365-9615 PMID: 6221770 Document Number: 210016
Mouse alloantiserum obtained by immunization of/DBA/2X XB10. A (3R)/F1 hybrids with thymic lymphocytes stimulated with Con A of B10.A(%) mice (anti-I-Jk) was tested in the microcytotoxic assay and in functional test of the survival of mice infected with tuberculosis. Serum was found to react with population of the cells from the lymph nodes of A/Sh, A2G, B10.AKM, and A.TL (I-Jk) mice, and was not active with B10.HTT (I-Js), B10 (I-Jb), B10,D2 (R107) (I-Jb), B6-H-2bm3 (I-Jb). Administration of the antiserum to mice infected with tuberculosis made the survival of the I-Jk-bearing strains significantly longer.