Early loss of measles antibodies after MMR vaccine among HIV-infected adults receiving HAART
Belaunzarán-Zamudio, P.F.; García-León, M.L.; Wong-Chew, R.M.ía.; Villasís-Keever, A.; Cuellar-Rodríguez, J.; Mosqueda-Gómez, J.L.; Muñoz-Trejo, T.; Escobedo, K.; Santos, J.é I.; Ruiz-Palacios, G.M.; Sierra-Madero, J.G.
Vaccine 27(50): 7059-7064
2009
ISSN/ISBN: 1873-2518 PMID: 19799846 DOI: 10.1016/j.vaccine.2009.09.063Document Number: 208991
The objective of the study was to evaluate the immune response to measles vaccine of HIV-infected adults in comparison to HIV non-infected adults. We conducted a cross-sectional study to identify adults lacking measles antibodies. 26 HIV-infected patients and 22 controls found to be measles seronegative in the cross-sectional study, received the MMR vaccine. We prospectively followed patients and measured measles antibodies, and cellular proliferative responses against measles antigens. We registered all adverse events at baseline, 3 and 12 months after vaccination. We determined measles antibodies by ELISA and cellular proliferative response in PBMC's at baseline, and repeated measurements at 3 and 12 months after vaccination. The humoral immune response to the vaccine between HIV-infected adults and the HIV-uninfected group was not statistically different at 3 months (81% vs. 86% respectively). One year after vaccination, a higher proportion of HIV-infected adults had lost measles antibodies in contrast to controls. The cellular response was not statistically different between the groups at baseline, 3 and 12 months after immunization despite the waning of antibodies at 12 months. No severe adverse events were observed. Most patients were receiving HAART and had a mean CD4+ cell count of 496 cells/mL. The initial humoral immune response to measles vaccine was not different between HIV-infected adults and HIV-uninfected adults. However, HIV-infected adults have a rapid decline of measles antibodies despite their high CD4+ cell count and sustained cellular proliferative response.
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