Several indices of humoral anti-measles immunity in children, previously immunized with live measles vaccine, who have developed measles
Tikhonova, N.T.; Khrometskaia, T.M.; Livanova, L.V.; Poliakova, T.A.; Azarova, S.A.
Voprosy Virusologii 3: 322-327
1978
ISSN/ISBN: 0507-4088 PMID: 695522 Document Number: 138173
The dynamics of the total content of measles antibody with reference to their physico-chemical nature and the dynamics of the content of the main classes of serum immunoglobulins (A, M, G) in children previously vaccinated and not vaccinated with live measles vaccine who developed measles were studied. Measles in the vaccines was found to run a course of the type of primary and secondary infection. In the former case, the normal dynamics of specific antibody was found with timely change of synthesis of antibody of various physico-chemical nature. In the latter case, immunity to measles developed according to the secondary type and was characterized by the absence of IgM measles antibody. The secondary immunological response was also characterized by higher antibody titers in the first days of the disease and decreased content of IgG and IgM in sera in the convalescent stage. Besides, in such children, hyperthermia occurred 3 times less frequently.