Morphological changes in organs of mice induced by the combination of adriamycin and pustulan
Fiszer-Maliszewska, L.; Mordarski, M.; Madej, J.A.; Kotz, J.
Archivum Immunologiae et Therapiae Experimentalis 31(3): 365-372
1983
ISSN/ISBN: 0004-069X PMID: 6651486 Document Number: 208196
In CDF1 mice treated with the combination of pustulan (50 mg/kg) and a low dose of adriamycin . Similar morphological changes, though generally less pronounced, were observed in mice treated with a high dose of adriamycin (20 mg/kg). The myocardial lesions were found in mice treated with the high dose of adriamycin or the combination of pustulan with the low dose of adriamycin. Morphological changes in the myocardium, as opposed to those in the liver were not reversible. No considerable changes were senn in organs of mice treated with pustulan at a dose of 50 mg/kg.