Effects of bupropion on body weight
Harto-Truax, N.; Stern, W.C.; Miller, L.L.; Sato, T.L.; Cato, A.E.
Journal of Clinical Psychiatry 44(5 Part 2): 183-186
1983
ISSN/ISBN: 0160-6689 PMID: 6406454 Document Number: 207921
Patients' weights were assessed during placebo-controlled, amitriptyline-controlled, and uncontrolled bupropion trials. Low-moderate (50-450 mg/day) to moderate-high (300-750 mg/day) doses of bupropion were consistently associated with a lack of weight gain (average weight loss of 1-2 pounds); placebo was associated with an average weight gain of 1 lb and 75-225 mg/day of amitriptyline was associated with an increase of 3-9 lb. Bupropion treatment was rarely accompanied by reports of appetite change and had no statistically significant effect on caloric intake when compared to placebo.