Sampling protocol for thyrotropin stimulation test in the dog
Oliver, J.W.; Waldrop, V.
Journal of the American Veterinary Medical Association 182(5): 486-489
1983
ISSN/ISBN: 0003-1488 PMID: 6833085 Document Number: 207436
A study was designed to assess the secretory response of thyroid glands in dogs to small doses of thyrotropin (thyroid-stimulating hormone, TSH; 2.5 and 5.0 units, total i/v dose), and to establish valid blood-sampling periods in cases in which thyroxine concentrations were different from base-line values. Significant response occurred as early as three hours after TSH administration, with a peak response at 5-7 hours. Food deprivation for 12 hours had no effect on test results. Because base-line thyroxine concentrations in dogs are equivocal and base-line triiodothyronine concentrations are influenced by many factors, thyrotropin stimulation testing is one of the best methods at present to evaluate thyroid function. Administration of a total dose of 2.5-5.0 units of TSH is economical, and collection of the 2nd blood sample as early as three hours for response may be advantageous in terms of scheduling for the client and practising veterinarian.