Plasmapheresis in Rh hemolytic disease: the danger of amniocentesis
Grant, C.J.; Hamblin, T.J.; Smith, D.S.; Wellstead, L.
International Journal of Artificial Organs 6(2): 83-86
1983
ISSN/ISBN: 0391-3988 PMID: 6404844 Document Number: 207083
We have treated 25 women with poor obstetric histories and high levels of anti-Rh antibodies by plasmapheresis during pregnancy. One baby was Rs negative, but 13 of the remaining 24 babies survived. Most of the foetal deaths were associated with a rapid rise in antibody level uncontrollable by plasmapheresis and which followed either amniocentesis or intra-uterine transfusion. Plasmapheresis throughout pregnancy with early delivery and avoidance of amniocentesis is recommended.