Immunohistological studies on the identification of T cells and T cell subsets infiltrating in human stomach cancer tissues
Kasai, K.; Imamura, M.; Hiratsuka, H.; Usui, T.; Kamiya, H.; Muroya, K.; Narimatsu, H.; Minase, A.; Totsuka, M.; Kikuchi, K.
Gan no Rinsho. Japan Journal of Cancer Clinics 29(9): 981-986
1983
ISSN/ISBN: 0021-4949 PMID: 6352990 Document Number: 206717
T cells and T cell subsets in human gastric cancer tissues were identified using the immunoperoxidase technique with anti-T cell monoclonal antibodies (Leu-1, Leu-2, Leu-3 and Leu-4), anti-HLA-DR(Ia) monocronal antibody, and anti-Ig sera. The majority of lymphocytes infiltrating into gastric cancer tissues were Leu-1 and Leu-4 positive T cells; they consisted of a Leu-2 positive T cell subset (Tc/s) and a Leu-3 positive T cell subset (Th/i). Leu-2 positive T cells infiltrated the gastric cancer tissues of 6 patients with a moderate or marked degree of lymphocyte infiltration; Leu-3 positive T cells infiltrated these tissues of 11 patients. These results show that the degree of T cell and T cell subset infiltration may effect the host-tumor relationship.