Bioavailability of sulfathiazole from flocculated and deflocculated suspensions and its implications
Rambhau, D.; Gudsoorkar, V.R.; Rao, Y.M.
Indian Journal of Physiology and Pharmacology 27(3): 217-220
1983
ISSN/ISBN: 0019-5499 PMID: 6668053 Document Number: 205922
Flocculation is commonly used to stabilize pharmaceutical suspensions. Flocculated and deflocculated suspensions of sulfathiazole were administered to healthy human volunteers. Bioavailability from these two types of suspensions was studied from urinary free drug excretion. Bioavailability was significantly lower from flocculated suspensions. The study indicates the necessity of studying all flocculated drug suspensions for bioavailability data.