IDM release behavior and surface characteristics of the novel Cu/IDM/LDPE nanocomposite for intrauterine device
Yang, Z.; Xie, C.; Xiang, H.; Feng, J.; Xia, X.; Cai, S.
Colloids and Surfaces. B Biointerfaces 69(2): 276-280
2009
ISSN/ISBN: 1873-4367 PMID: 19124230 DOI: 10.1016/j.colsurfb.2008.11.027Document Number: 205481
Copper/indomethacin/low-density polyethylene (Cu/IDM/LDPE) nanocomposite was prepared as a novel material for intra-uterine device (IUD). IDM release profile of the nanocomposite was investigated by using spectrophotometer. The results show that IDM release rate of Cu/IDM/LDPE nanocomposite is higher in simulated uterine solution than that in methanol, confirming that the release process of IDM is dominated mainly by pore diffusion. The decrease in copper particle size and the increase in copper mass content all accelerate IDM release, indicating that IDM release rate can be adjusted by changing copper loading or copper particle size. The surface of the incubated nanocomposite was characterized by X-ray diffraction, scanning electron microscopy and energy dispersive X-ray microanalysis. A few deposits composed of P, Cl, Ca, Cu and O were observed on the nanocomposite surface, which may be related to the presence of IDM particles with large particle size.
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