Estrogen-induced bone marrow depression in ferrets
Bernard, S.L.; Leathers, C.W.; Brobst, D.F.; Gorham, J.R.
American Journal of Veterinary Research 44(4): 657-661
1983
ISSN/ISBN: 0002-9645 PMID: 6683476 Document Number: 203037
The administration of estrogen-induced severe bone marrow depression in 9 of 12 ferrets, independent of sex (male, female) or ovariohysterectomy. Resultant pancytopenia was manifested by subcutaneous petechiae, melena, hematomyelia, pale mucous membranes, pale bone marrow, centrilobular hepatic degeneration, hydrometra, and pyometra. These findings are compatible with the naturally occurring estrus-associated anemia seen in female ferrets.
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