Evaluation of the potential of synthetic peptides of 80 kDa human sperm antigen (80 kDaHSA) for the development of contraceptive vaccine for male
Khobarekar, B.G.; Vernekar, V.; Raghavan, V.; Kamada, M.; Maegawa, M.; Bandivdekar, A.H.
Vaccine 26(29-30): 3711-3718
2008
ISSN/ISBN: 0264-410X PMID: 18514978 DOI: 10.1016/j.vaccine.2008.04.060Document Number: 201380
80 kDaHSA has been demonstrated to be responsible for inducing immunoinfertility. Synthetic peptides NT, 1, 2 and 4 of 80 kDaHSA are immunogenic and immunobiologically mimic the native protein. Peptides 1 and NT being highly immunogenic their potential for contraceptive vaccine development was evaluated. Active immunization of male rabbits with peptide-1 and -NT induced reversible infertility in 100% and 60% of animals, respectively and subsequently active immunization of non-human primate model, male marmosets with peptide-1 induced reversible infertility in six out of seven high antibody titer animals. The present study suggests the potential of peptide-1 of 80 kDaHSA for the development of contraceptive vaccine.
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