Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the amazon region of Peru

Zhou, Z.; Griffing, S.M.; de Oliveira, A.Macedo.; McCollum, A.M.; Quezada, W.Marquino.; Arrospide, N.; Escalante, A.A.; Udhayakumar, V.; Zhou, Z; Griffing, S.M; de Oliveira, A.Macedo; McCollum, A.M; Quezada, W.Marquino; Arrospide, N; Escalante, A.A; Udhayakumar, V

doi:10.1128/aac.00297-08

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Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the amazon region of Peru

Zhou, Z.; Griffing, S.M.; de Oliveira, A.Macedo.; McCollum, A.M.; Quezada, W.Marquino.; Arrospide, N.; Escalante, A.A.; Udhayakumar, V.

Antimicrobial Agents and Chemotherapy 52(2): 739-741

2008

ISSN/ISBN: 0066-4804

PMID: 18025120

DOI: 10.1128/aac.00297-08

Document Number: 199947

The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin.