Top Abstract Purchase Related
Home
>
Node
>
Subnode

Plasma protein binding of fentanyl: the effect of hyperlipoproteinaemia and chronic renal failure

Bower, S.

Journal of Pharmacy and Pharmacology 34(2): 102-106

1982

ISSN/ISBN: 0022-3573
PMID: 6121867
Document Number: 196696
Hyperlipoproteinemic patients with raised pre-.beta.- or pre-.beta.- and .beta.-lipoprotein fractions showed a significant (P < 0.001) increase in binding of fentanyl to whole plasma, compared with normal subjects. The presence of chylomicra had no significant effect on binding. In patients with chronic renal failure, a correlation of probability (P < 0.07) was found between percent binding and concentrations of pre-.beta.-lipoprotein (P = 0.001), serum albumin (P = 0.0101), total protein minus albumin (P = 0.0576) and .beta.-lipoprotein (P = 0.0625). There was no significant correlation of binding with elevation of .alpha.- or .gamma.-globulins, with urea or creatinine concentrations, or with age or sex (P .gtoreq. 0.223). The magnitude of changes in the free fraction found in these patients should not produce a clinical effect as the total distribution volume of fentanyl exceeds 200 l.

Document emailed within 1 workday
Secure & encrypted payments

Adoncecchi, L.; Marrocco, W.; Suraci, C.; Pecora, P.; Gallinella, B.; Porrà, R.; Cavina, G. 1984: Effect of renal and liver failure on blood levels of vitamin A, its precursor (beta-carotene) and its carrier proteins (prealbumin and retinol binding protein) Bollettino della Societa Italiana di Biologia Sperimentale 60(4): 881-886
Hou, J.S.; Zuo, J.N.; Zhu, H.W.; Ma, J.M.; Feng, H.F.; Cheng, W.Y.; Zhang, X.Q.; Wu, J.Z.; Wu, J.C.; Zhang, M.W. 1985: Effect of low protein diet on whole body nitrogen metabolism in patients with chronic renal failure Chinese Medical Journal 98(10): 765-770
Samsonov, M.A.; Vysotskiĭ, V.G.; Iatsyshina, T.A.; Agadzhanov, S.A.; Vitollo, A.S. 1982: Effect of dietary proteins of different quality on protein metabolism in the initial stage of chronic renal failure Terapevticheskii Arkhiv 54(10): 67-69
Denisova, S.N.; Kutafina, E.K.; Sergeeva, T.V.; Savina, M.I.; Kon', I.I.; Shilina, N.M.; Chizhevskaia, O.L.; Shilov, A.V. 1998: Effect of vitamin D metabolites on the markers of protein, calcium and phosphorus turnover in children with chronic renal failure Voprosy Pitaniia 1: 14-17
Korczyńska, J.; Stelmańska, E.; Nieweglowski, T.; Szołkiewicz, M.; Rutkowski, B.; Swierczyński, J. 2000: Effect of clofibrate on plasma lipid concentration and liver malic enzyme gene expression in rats with experimental chronic renal failure Polish Journal of Pharmacology 52(4): 291-297
Pacifici, G.M.; Viani, A.; Rizzo, G.; Carrai, M.; Ganansia, J.; Bianchetti, G.; Morselli, P.L. 1988: Plasma protein binding of zolpidem in liver and renal insufficiency International Journal of Clinical Pharmacology Therapy and Toxicology 26(9): 439-443
Oimomi, M.; Ishikawa, K.; Kawasaki, T.; Kubota, S.; Yoshimura, Y.; Baba, S. 1983: Plasma carbamylated protein in renal failure New England Journal of Medicine 308(11): 655-656
Beyer, C.; Boekhout, M.; van Iperen, H. 1994: Bromcresol purple dye-binding and immunoturbidimetry for albumin measurement in plasma or serum of patients with renal failure Clinical Chemistry 40(5): 844-845
Krumlovsky, F.A. 1981: Disorders of protein and lipid metabolism associated with chronic renal failure and chronic dialysis Annals of Clinical and Laboratory Science 11(4): 350-360
Liu, J.H.; Malone, R.S.; Stallings, H.; Smith, P.C. 1996: Influence of renal failure in rats on the disposition of salicyl acyl glucuronide and covalent binding of salicylate to plasma proteins Journal of Pharmacology and Experimental Therapeutics 278(1): 277-283
Ellekilde, G.; Holm, J.; von Eyben, F.E.; Hemmingsen, L. 1992: Above-normal urinary excretion of albumin and retinol-binding protein in chronic heart failure Clinical Chemistry 38(4): 593-594
Ma, J.M.; Zhu, H.W.; Chen, W.Y. 1988: Changes in plasma and urinary tryptophan in chronic renal failure Zhonghua Nei Ke Za Zhi 27(3): 153-6 197
Pacifici, G.M.; Viani, A.; Rizzo, G.; Carrai, M. 1989: Plasma protein binding of ethinyloestradiol: effect of disease and interaction with drugs International Journal of Clinical Pharmacology Therapy and Toxicology 27(7): 362-365
Ramsay, G.; Ledingham, I.M. 1987: Resuscitation in haemorrhagic shock--pulmonary and renal effects: an adverse effect of stabilised plasma protein solution on renal function? Circulatory Shock 22(3): 261-268
Hoffer, L.J. 1999: Optimum protein intake in chronic renal failure Diabetes Nutrition and Metabolism 12(6): 435-439
Chen, J.H.; Tsai, J.H.; Lai, Y.H.; Hwang, S.J. 1990: Plasma atrial natriuretic peptide in patients with chronic renal failure Journal of the Formosan Medical Association 89(8): 645-650
Zhu, J.; Xiong, X.; Zhao, S.; Wang, Z.; Lou, L.; Hang, Q. 1999: Plasma Lp (a) levels and correlation of Lp (a) with fibrinolysis activation in chronic renal failure Hunan Yi Ke da Xue Xue Bao 24(4): 366-368
Herselman, M.G.; Albertse, E.C.; Lombard, C.J.; Swanepoel, C.R.; Hough, F.S. 1995: Supplemented low-protein diets--are they superior in chronic renal failure? South African Medical Journal 85(5): 361-365
Szczepańska, M.; Szprynger, K.; Mazur, B.; Zwolińska, D.; Kiliś-Pstrusińska, K.; Makulska, I. 2007: Plasma ghrelin levels in children with chronic renal failure on peritoneal dialysis Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 27(1): 61-66
Li, J.-l.; Zheng, F.-l.; Tan, H.-b.; Yin, S.-y.; Yang, J.-h.; Li, Y.; Bu, Y.-f. 2003: Orexin a and neuropeptide y levels in plasma and hypothalamus of rats with chronic renal failure Zhonghua Yi Xue Za Zhi 83(11): 992-995