High-dose AMSA and bone marrow rescue in patients with solid tumors
Zander, A.R.; Spitzer, G.; Legha, S.; Dicke, D.A.; Verma, D.S.; Johnston, D.A.; Vellekoop, L.; Beran, M.; Schell, F.; Minnhaar, G.; Blumenschein, G.R.; Bodey, G.P.
Cancer Treatment Reports 66(2): 385-386
1982
ISSN/ISBN: 0361-5960 PMID: 7034935 Document Number: 196636
The feasibility of high-dose AMSA followed by autologous bone marrow rescue was studied in seven patients with solid tumors. They received a total of 12 courses of treatment. Total doses ranged from 600 to 1000 mg/m2/course. Major toxic effects were myelosuppression, fever of unknown origin, and stomatitis. One patient with malignant melanoma had stable disease lasting 2 months; the other six had progressive disease.
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