The effect of pyridoxine-alpha-ketoglutarate (PAK) on exercise-induced increase of blood lactate in patients with type i diabetes
Dall'Aglio, E.; Zavaroni, I.; Alpi, O.; Coscelli, C.; Butturini, U.
International Journal of Clinical Pharmacology Therapy and Toxicology 20(3): 147-150
1982
ISSN/ISBN: 0174-4879 PMID: 7068289 Document Number: 196530
Administration of pyridoxine-alpha-ketoglutarate (PAK) to a group of insulin-independent non-ketotic diabetics decreased (p less than 0.01) the plasma concentration of lactate response to isometric exercise. The mechanism of action of PAK could be interpreted as a consequence of changes induced by the drug on the Krebs' cycle with a subsequent reduction of lactate production.
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