Lymphocytes as inducers of mitoses of human morphologically identifiable progenitor cells. Phase contrast observations
Boll, I.T.; Domeyer, C.
Experimental Hematology 10(4): 326-331
1982
ISSN/ISBN: 0301-472X PMID: 7047181 Document Number: 196506
Phase contrast time lapse observations of human bone marrow cells demonstrate the induction of progenitor cell mitoses or amitoses by the touch of locomotive lymphocytes on the cell surface. Interkinetic progenitor cells as well as precursor cells before mitosis were very rarely touched by lymphocytes. This cell-cell interaction is apparently essential in the T-cell participation in hematopoietic stem cell proliferation.
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