Lymphocytes as inducers of mitoses of human morphologically identifiable progenitor cells. Phase contrast observations

Boll, I.T.; Domeyer, C.

Experimental Hematology 10(4): 326-331

1982


ISSN/ISBN: 0301-472X
PMID: 7047181
Document Number: 196506
Phase contrast time lapse observations of human bone marrow cells demonstrate the induction of progenitor cell mitoses or amitoses by the touch of locomotive lymphocytes on the cell surface. Interkinetic progenitor cells as well as precursor cells before mitosis were very rarely touched by lymphocytes. This cell-cell interaction is apparently essential in the T-cell participation in hematopoietic stem cell proliferation.

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