Side Effects and toxicity of lithium
Apter, J.T.; Apter, A.S.; Tyano, S.
Journal of Family Practice 15(6): 1101-1106
1982
ISSN/ISBN: 0094-3509 PMID: 6128370 Document Number: 196295
Although lithium remains the most specific treatment for bipolar affective disorder, it should be cautiously prescribed and used only when clinically indicated. The main indications for lithium are the manic phase of bipolar affective disorder and prophylaxis of both manic and depressive episodes. Lowering serum lithium levels will markedly reduce the incidence of side effects, and patients should be maintained at the lowest possible serum level. The serum level may be as low as 0.4 mEq/L and as high as 1.5 mEq/L, depending on the clinical response of the patient and the presence of side effects. The most controversial areas are the possibility of renal toxicity and the concomitant use of lithium with neuroleptics, especially haloperidol.