Ursodeoxycholic acid in the treatment of gallbladder lithiasis
Mamianetti, A.; Labonia, N.A.; Lafont, D.; Fiordalisi, H.H.
Acta Gastroenterologica Latinoamericana 12(1): 33-38
1982
ISSN/ISBN: 0300-9033 PMID: 7136453 Document Number: 195787
22 patients with radiolucid stones and functioning gallbladder were grouped to establish ursodeoxycholic acid efficacy (i.e. gallstones dissolution) and innocuousness for gallbladder lithiasis. Methodological aspects were detailed, the dose determined (8 and 10 mg/k/d.) and the patients evaluated after a six months' treatment. 11 patients received "day-time" doses and the other 11 "overnight" dose. Only 7 subjects turned out to be evaluated for the study of biliary lipids, to the other 15 the development of their gallstones was followed up. Successful gallstone dissolution was achieved in 8 patients (53,3%), 2 reduced size and number. 5 out of these 8 patients received "day-time" doses and the other 3 "overnight" doses. From an attendance point of view, we do not consider biliary lipids study (bile cholesterol saturation rate) to be necessary.