Anticentromere antibodies. Diagnostic and prognostic value
Meyer, O.; Haïm, T.
La Nouvelle Presse Medicale 11(39): 2891-2894
1982
ISSN/ISBN: 0301-1518 PMID: 6755388 Document Number: 195148
The results of investigations for antinuclear antibodies in scleroderma and other connective diseases are reported. An indirect fluorescence method on Hep-2 cell smears was used. Antibodies directed against chromosomal centromeres were detected in 25 cases: 19 sera of patients with diffuse scleroderma, 2 cases of Raynaud's disease, 2 cases of rheumatoid arthritis and 1 case each of lupus and dermatomyositis. A significant correlation was found between the presence of anticentromere antibodies and benign forms of scleroderma, notably the CREST syndrome.