Monoclonal immunoglobulin-secreting lymphoma in a patient with severe combined immunodeficiency disease
Shirley, L.R.; Buckley, R.H.; Borowitz, M.J.; Welt, S.I.; Kostyu, D.D.
Clinical and Experimental Immunology 48(3): 666-674
1982
ISSN/ISBN: 0009-9104 PMID: 6811170 Document Number: 194710
A 3.5 year old boy with X-linked severe combined immunodeficiency disease (SCID), who had been in laminar flow isolation throughout his life, developed a B cell tumour producing up to 3008 mg/dl of an IgM kappa paraprotein 1 month after infusion of both liver and thymus cells from a fetal donor and 6 months after the last of six fetal liver cell infusions given over a 3 year period. Pretransplant studies revealed a high percentage of circulating B lymphocytes. HLA typing suggests that the tumour was of host origin.