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Statin specific toxicity in organ transplant recipients: case report and review of the literature

Bae, J.; Jarcho, J.A.; Denton, M.D.; Magee, C.C.

Journal of Nephrology 15(3): 317-319

2002

ISSN/ISBN: 1121-8428
PMID: 12113605
Document Number: 1945
Statins are widely prescribed to organ transplant recipients with hyperlipidemia. We report the case of a cardiac transplant recipient who developed severe rhabdomyolysis and acute renal failure after being switched from pravastatin to simvastatin. The patient's other medications included cyclosporin A and diltiazem. Unlike pravastatin, the metabolism and tissue concentrations of simvastatin - and of other statins - can be greatly affected by these drugs. The propensity of the individual statins to interact with drugs commonly prescribed to transplant recipients is reviewed.

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Statin specific toxicity in organ transplant recipients: case report and review of the literature

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