Interactions between the growth effects of a kidney epithelial cell growth inhibitor and extracellular concentrations of cyclic nucleotides
Fremuth, F.; Holley, R.W.; Baldwin, J.H.
Neoplasma 29(3): 295-300
1982
ISSN/ISBN: 0028-2685 PMID: 6290910 Document Number: 194218
The effect of dibutyryl cells was studied in the presence and absence of kidney epithelial cell growth inhibitor. The growth response of the cells was dependent on concentrations of the dibutyryl cyclic nucleotides and on the presence or absence of serum in the medium. In the presence of serum, a high concentration (10-3 M) of dbcGMP largely overcame the action of the kidney epithelial cell growth inhibitor. In the absence of serum, a high concentration (10-3 M) of dbcAMP increased growth inhibition observed with the growth inhibitor. In the presence of serum, low concentrations of dbcAMP were growth stimulatory and partially overcame the action of the growth inhibitor.